Safety & Who Should Not Use Mantra

Psilocybin has a well-established safety profile and low potential for physical dependence when used responsibly. However, it is not appropriate for everyone. Understanding these contraindications before purchasing is essential — not optional.

Do Not Use If You…

Are under 21 years of age
Are pregnant or breastfeeding
Have personal or family history of psychosis, schizophrenia, or bipolar I
Are taking MAOIs or antidepressants (SSRIs)
Are taking lithium or tramadol
Have severe cardiovascular conditions
Are colorblind (may cause uncomfortable visual effects)
Have severe anxiety or active suicidal ideation

Best Practices for Safe Use

Start with the lowest recommended dose
Use in a comfortable, familiar environment
Clear your full schedule for the day
Have a trusted, sober companion present
Do not operate vehicles or machinery
Stay hydrated — have water available
Set a clear, positive intention beforehand
Research “set and setting” before your first experience

About Drug Interactions

Psilocybin can interact with certain medications. The most important interactions to understand:

MAOIs: Dangerous interaction — can cause serotonin syndrome. Do not combine under any circumstances.
SSRIs & SNRIs: May reduce or block psilocybin effects due to serotonin receptor competition. Do not stop prescribed antidepressants without consulting your physician.
Lithium: Can increase risk of seizures. Avoid combination.
Tramadol: Risk of seizures and serotonergic effects. Avoid combination.

If you take any prescription medication, consult your healthcare provider before using any psilocybin product.

Possible Side Effects

Common, generally mild side effects include: nausea during onset, increased heart rate, pupil dilation, mild anxiety during come-up, muscle tension, yawning, and temperature sensitivity. These are temporary and resolve as effects develop. Taking Mantra chocolate with a small amount of ginger or on a light stomach can reduce nausea for sensitive individuals.

Physical overdose from psilocybin is extremely rare — toxic doses are far above any recreational amount. However, taking too much can result in overwhelming psychological distress, severe anxiety, and temporary disconnection from reality. This is why starting low and waiting the full onset period is non-negotiable. If you are concerned about a severe experience, call a trusted person or reach out to a harm reduction service like Zendo Project or Fireside Project (1-62-FIRESIDE).